Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-<i>b</i>]furan-5,10-diones in Hepatocellular Carcinoma Cells

Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-<i>b</i>]furan-5,10-diones in Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the most frequent primary malignancy of the liver and is among the top three causes of cancer-associated death worldwide. However, the clinical use of chemotherapy for HCC has been limited by various challenges, emphasizing the urgent need for novel agents with impr...

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Bibliographic Details
Main Authors: Chia-Yang Lin, Atikul Islam, Claire J. Su, Alexander S. Tikhomirov, Andrey E. Shchekotikhin, Show-Mei Chuang, Pin Ju Chueh, Yao Li Chen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
apoptosis
anthraquinone derivatives
hepatocellular carcinoma
p53
tumor-associated NADH oxidase (tNOX or ENOX2)
sirtuin 1 (SIRT1)
c-Myc
protein acetylation
Online Access:https://www.mdpi.com/2072-6694/11/3/420

Internet

https://www.mdpi.com/2072-6694/11/3/420

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