Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezers

Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezers

Abstract Background Chemotherapeutic agents (anti-cancer drugs) are small cytostatic or cytotoxic molecules that often bind to double-stranded DNA (dsDNA) resulting in modifications of their structural and nanomechanical properties and thus interfering with the cell proliferation process. Methods We...

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Bibliographic Details
Main Authors: Dennis Kreft, Ying Wang, Michael Rattay, Katja Toensing, Dario Anselmetti
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Nanobiotechnology
Subjects:
Mitoxantrone
DNA
Magnetic tweezers
Intercalator
Groove binder
Online Access:http://link.springer.com/article/10.1186/s12951-018-0381-y

Internet

http://link.springer.com/article/10.1186/s12951-018-0381-y

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