Perforant Path Fiber Loss Results in Mnemonic Discrimination Task Deficits in Young Rats

The observation that entorhinal input to the hippocampus declines in old age is well established across human studies and in animal models. This loss of perforant path fibers is exaggerated in individuals with episodic memory deficits and Mild Cognitive Impairment, suggesting that perforant path int...

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Bibliographic Details
Main Authors: Sara N. Burke, Sean M. Turner, Courtney L. Desrosiers, Sarah A. Johnson, Andrew P. Maurer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Systems Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2018.00061/full