Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice

Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice

Summary: Alzheimer’s disease (AD) is characterized by neurodegeneration, memory loss, and social withdrawal. Brain inflammation has emerged as a key pathogenic mechanism in AD. We hypothesized that oxytocin, a pro-social hypothalamic neuropeptide with anti-inflammatory properties, could have therape...

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Bibliographic Details
Main Authors: Maria Clara Selles, Juliana T.S. Fortuna, Yasmin P.R. de Faria, Luciana Domett Siqueira, Ricardo Lima-Filho, Beatriz M. Longo, Robert C. Froemke, Moses V. Chao, Sergio T. Ferreira
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Molecular physiology
Neuroscience
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223006223

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223006223

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