Preparation and in vitro release kinetics of ivermectin sustained-release bolus optimized by response surface methodology

Sustained-release formulations of ivermectin (IVM) are useful for controlling parasitic diseases in animals. In this work, an IVM bolus made from microcrystalline cellulose (MCC), starch and low-substituted hydroxypropyl cellulose (LS-HPC) was optimized by response surface methodology. The bolus was...

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Bibliographic Details
Main Authors: Xiangchun Ruan, Xiuge Gao, Ying Gao, Lin Peng, Hui Ji, Dawei Guo, Shanxiang Jiang
Format: Article
Language:English
Published: PeerJ Inc. 2018-07-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/5418.pdf