QSAR Studies, Molecular Docking, Molecular Dynamics, Synthesis, and Biological Evaluation of Novel Quinolinone-Based Thiosemicarbazones against <i>Mycobacterium tuberculosis</i>

QSAR Studies, Molecular Docking, Molecular Dynamics, Synthesis, and Biological Evaluation of Novel Quinolinone-Based Thiosemicarbazones against <i>Mycobacterium tuberculosis</i>

In this study, a series of novel quinolinone-based thiosemicarbazones were designed in silico and their activities tested in vitro against <i>Mycobacterium tuberculosis</i> (<i>M. tuberculosis</i>). Quantitative structure-activity relationship (QSAR) studies were performed us...

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Bibliographic Details
Main Authors: Jhesua Valencia, Vivian Rubio, Gloria Puerto, Luisa Vasquez, Anthony Bernal, José R. Mora, Sebastian A. Cuesta, José Luis Paz, Braulio Insuasty, Rodrigo Abonia, Jairo Quiroga, Alberto Insuasty, Andres Coneo, Oscar Vidal, Edgar Márquez, Daniel Insuasty
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antibiotics
Subjects:
<i>Mycobacterium tuberculosis</i>
QSAR
docking
quinolinone
thiosemicarbazone
molecular dynamics and cytotoxicity
Online Access:https://www.mdpi.com/2079-6382/12/1/61

Internet

https://www.mdpi.com/2079-6382/12/1/61

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