Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable

Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable

Water-soluble formulations of the pyrazole derivative 3-(4-chlorophenyl)-5-(4-nitrophenylamino)-1<i>H</i>-pyrazole-4-carbonitrile (CR232), which were proven to have in vitro antiproliferative effects on different cancer cell lines, were prepared by two diverse nanotechnological approache...

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Bibliographic Details
Main Authors: Silvana Alfei, Andrea Spallarossa, Matteo Lusardi, Guendalina Zuccari
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Nanomaterials
Subjects:
fifth-generation polyester-based lysine-modified dendrimer
physical encapsulation
3-(4-chloro-phenyl)-5-(4-nitro-phenylamino)-1<i>H</i>-pyrazole-4-carbonitrile (CR232)
water-soluble CR232-loaded dendrimer NPs
water-soluble CR232-loaded liposomes
spherical morphology
Online Access:https://www.mdpi.com/2079-4991/12/2/233

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https://www.mdpi.com/2079-4991/12/2/233

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