Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates

Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates

We developed a bioinformatics-led substrate discovery workflow to expand the known substrate repertoire of MALT1. Our approach, termed GO-2-Substrates, integrates protein function information, including GO terms from known substrates, with protein sequences to rank substrate candidates by similarity...

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Bibliographic Details
Main Authors: Peter A. Bell, Sophia Scheuermann, Florian Renner, Christina L. Pan, Henry Y. Lu, Stuart E. Turvey, Frédéric Bornancin, Catherine H. Régnier, Christopher M. Overall
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Protease
MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
CBM
Proteolytic processing
Proteolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003555

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http://www.sciencedirect.com/science/article/pii/S2001037022003555

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