Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two αSN FRET biosensors provide complementary insight in...

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Bibliographic Details
Main Authors: Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-021-00195-6

Internet

https://doi.org/10.1038/s41531-021-00195-6

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