Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of rare neurodegenerative inherited disorders. The resulting motor incoordination and progressive functional disabilities lead to reduced lifespan. There is currently no cure for ARCAs, likely attributed to the lack of understa...

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Bibliographic Details
Main Authors: Sze Yuen Lew, Michael Weng Lok Phang, Pit Shan Chong, Jaydeep Roy, Chi Him Poon, Wing Shan Yu, Lee Wei Lim, Kah Hui Wong
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceuticals
Subjects:
autosomal recessive cerebellar ataxia
rare neurodegenerative disease
genetic mutation
preclinical model
oxidative stress
antioxidant pathway and therapy
Online Access:https://www.mdpi.com/1424-8247/15/6/764

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https://www.mdpi.com/1424-8247/15/6/764

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