Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.

Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.

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Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of cancer cells independent of its inhibition of th...

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Bibliographic Details
Main Authors: Christian Mayr, Tobias Kiesslich, Dino Bekric, Marlena Beyreis, Michael Kittl, Celina Ablinger, Elen Neureiter, Martin Pichler, Felix Prinz, Markus Ritter, Daniel Neureiter, Martin Jakab, Heidemarie Dobias
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0287769

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https://doi.org/10.1371/journal.pone.0287769

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