Resistance of <i>Wolbachia</i> to Trimethoprim: Insights into Genes Encoding Dihydrofolate Reductase, Thymidylate Synthase and Serine Hydroxymethyltransferase in the Rickettsiales
Bacterial and eukaryotic dihydrofolate reductase (DHFR) enzymes are essential for DNA synthesis and are differentially sensitive to the competitive inhibitors trimethoprim and methotrexate. Unexpectedly, trimethoprim did not reduce <i>Wolbachia</i> abundance, and the <i>w</i>...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Insects |
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| Online Access: | https://www.mdpi.com/2075-4450/16/1/18 |