VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.

VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.

Upon phagocytosis, Legionella pneumophila translocates numerous effector proteins into host cells to perturb cellular metabolism and immunity, ultimately establishing intracellular survival and growth. VipD of L. pneumophila belongs to a family of bacterial effectors that contain the N-terminal lipa...

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Bibliographic Details
Main Authors: Bonsu Ku, Kwang-Hoon Lee, Wei Sun Park, Chul-Su Yang, Jianning Ge, Seong-Gyu Lee, Sun-Shin Cha, Feng Shao, Won Do Heo, Jae U Jung, Byung-Ha Oh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003082&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003082&type=printable

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