Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model

Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model

Abstract Background Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are often associated with airway fluid acidification. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to impaired bicarbonate secretion contributing to CF airway pathology...

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Bibliographic Details
Main Authors: Kata Csekő, Dóra Hargitai, Lilla Draskóczi, Adrienn Kéri, Pongsiri Jaikumpun, Beáta Kerémi, Zsuzsanna Helyes, Ákos Zsembery
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Pulmonary Medicine
Subjects:
Airways
Cystic fibrosis
COPD
Bicarbonate
pH
Inhalation
Online Access:https://doi.org/10.1186/s12890-022-01919-x

Internet

https://doi.org/10.1186/s12890-022-01919-x

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