Internal regulation between constitutively expressed T cell co-inhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants

Internal regulation between constitutively expressed T cell co-inhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants

Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expressed co-inhibitors and when they are needed is unknow...

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Bibliographic Details
Main Authors: Adeolu O. Adegoke, Govindarajan Thangavelu, Ting-Fang Chou, Marcos I. Petersen, Kiyokazu Kakugawa, Julia F. May, Kevin Joannou, Qingyang Wang, Kristofor K. Ellestad, Louis Boon, Peter A. Bretscher, Hilde Cheroutre, Mitchell Kronenberg, Troy A. Baldwin, Colin C. Anderson
Format: Article
Language:English
Published: The Royal Society 2024-10-01
Series:Open Biology
Subjects:
T cells
autoimmunity
BTLA
CD5
recent thymic emigrants
tolerance
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240178

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.240178

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