Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease

Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease

Chylomicron retention disease (CRD) is an autosomal recessive disorder associated with biallelic Sar1b mutations leading to defects in intracellular chylomicron (CM) trafficking and secretion. To date, a direct cause-effect relationship between CRD and Sar1b mutation has not been established, but ge...

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Bibliographic Details
Main Authors: Nickolas Auclair, Alain T. Sané, Lena Ahmarani, Nathalie Patey, Jean-François Beaulieu, Noel Peretti, Schohraya Spahis, Emile Levy
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
Sar1b
gene defects
embryonic lethality
chylomicron
dietary fat
lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521000675

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http://www.sciencedirect.com/science/article/pii/S0022227521000675

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