Design, synthesis and evaluation of cytotoxic, antimicrobial, and anti-HIV-1 activities of new 1,2,3,4-tetrahydropyrimidine derivatives

Design, synthesis and evaluation of cytotoxic, antimicrobial, and anti-HIV-1 activities of new 1,2,3,4-tetrahydropyrimidine derivatives

A series of new 1,2,3,4-tetrahydropyrimidine (THPM) derivatives were designed and synthesized within a one-pot three component Biginelli reaction. The structures of compounds were characterized by FT-IR, 1H- NMR, mass spectroscopy, and elemental analysis. All synthesized derivatives were screened fo...

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Bibliographic Details
Main Authors: Nima Razzaghi-Asl, Mahsa Kamrani-Moghadam, Behzad Farhangi, Rouhollah Vahabpour, Rezvan Zabihollahi, Saghi Sepehri
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
anti-hiv; antimicrobial; biginelli; neoplasm;1
2
3
4-tetrahydropyrimidine.
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2019;volume=14;issue=2;spage=155;epage=166;aulast=Razzaghi-Asl

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2019;volume=14;issue=2;spage=155;epage=166;aulast=Razzaghi-Asl

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