The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-<i>e</i>]tetrazolo[4,5-<i>b</i>][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells

The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-<i>e</i>]tetrazolo[4,5-<i>b</i>][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells

The discovery of cytotoxic drugs is focused on designing a compound structure that directly affects cancer cells without an impact on normal cells. The mechanism of anticancer activity is mainly related with activation of apoptosis. However, recent scientific reports show that autophagy also plays a...

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Bibliographic Details
Main Authors: Agnieszka Gornowicz, Anna Szymanowska, Mariusz Mojzych, Krzysztof Bielawski, Anna Bielawska
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer
apoptosis
autophagy
anticancer agents
roscovitine
5-fluorouracil
Online Access:https://www.mdpi.com/1422-0067/21/15/5221

Internet

https://www.mdpi.com/1422-0067/21/15/5221

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