Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders

The extracellular matrix (ECM) and membrane proteolysis play a key role in structural and functional synaptic plasticity associated with development and learning. A growing body of evidence underscores the multifaceted role of members of the metzincin superfamily, including metalloproteinases (MMPs)...

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Bibliographic Details
Main Authors: Patrycja Brzdak, Daria Nowak, Grzegorz Wiera, Jerzy W. Mozrzymas
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
metzincins
metalloproteinases
synaptic plasticity
learning
amyloid β
Alzheimer’s disease
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00178/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00178/full

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