Cold-adapted influenza and recombinant adenovirus vaccines induce cross-protective immunity against pH1N1 challenge in mice.

The rapid spread of the 2009 H1N1 pandemic influenza virus (pH1N1) highlighted problems associated with relying on strain-matched vaccines. A lengthy process of strain identification, manufacture, and testing is required for current strain-matched vaccines and delays vaccine availability. Vaccines i...

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Bibliographic Details
Main Authors: Mark R Soboleski, Jon D Gabbard, Graeme E Price, Julia A Misplon, Chia-Yun Lo, Daniel R Perez, Jianqiang Ye, S Mark Tompkins, Suzanne L Epstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3137593?pdf=render