Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis

Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all targeted and immune therapies. However, our understanding of PDAC microenvironment especially the metastatic microenvironment is very limited partly due to the inaccessibility to metastatic tumor tissue...

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Bibliographic Details
Main Authors: Shu Zhang, Wen Fang, Siqi Zhou, Dongming Zhu, Ruidong Chen, Xin Gao, Zhuojin Li, Yao Fu, Yixuan Zhang, Fa Yang, Jing Zhao, Hao Wu, Pin Wang, Yonghua Shen, Shanshan Shen, Guifang Xu, Lei Wang, Chao Yan, Xiaoping Zou, Dijun Chen, Ying Lv
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40727-7

Internet

https://doi.org/10.1038/s41467-023-40727-7

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