<i>N</i>,<i>N</i>-Diethyl-3-toluamide Formulation Based on Ethanol Containing 0.1% 2-Hydroxypropyl-β-cyclodextrin Attenuates the Drug’s Skin Penetration and Prolongs the Repellent Effect without Stickiness

<i>N</i>,<i>N</i>-Diethyl-3-toluamide Formulation Based on Ethanol Containing 0.1% 2-Hydroxypropyl-β-cyclodextrin Attenuates the Drug’s Skin Penetration and Prolongs the Repellent Effect without Stickiness

<i>N</i>,<i>N</i>-diethyl-3-toluamide (DEET) is one of the most widely used insect repellents in the world. It was reported that a solution containing 6–30% cyclodextrin (CD) as a solvent instead of ethanol (EtOH) provided an enhancement of the repellent action time duration...

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Bibliographic Details
Main Authors: Noriaki Nagai, Mayu Kawaguchi, Misa Minami, Kana Matsumoto, Tatsuji Sasabe, Kenji Nobuhara, Akira Matsubara
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
<i>N</i>,<i>N</i>-diethyl-3-toluamide
cyclodextrin
insect repellent
stickiness
skin penetration
Online Access:https://www.mdpi.com/1420-3049/27/10/3174

Internet

https://www.mdpi.com/1420-3049/27/10/3174

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