Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception

Abstract Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, including those signaling fast pain, were dependent on...

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Bibliographic Details
Main Authors: Julia Ojeda-Alonso, Laura Calvo-Enrique, Ricardo Paricio-Montesinos, Rakesh Kumar, Ming-Dong Zhang, James F. A. Poulet, Patrik Ernfors, Gary R. Lewin
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44845-8