Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception
Abstract Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, including those signaling fast pain, were dependent on...
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| Format: | Article |
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Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-44845-8 |
| _version_ | 1797273923010691072 |
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| author | Julia Ojeda-Alonso Laura Calvo-Enrique Ricardo Paricio-Montesinos Rakesh Kumar Ming-Dong Zhang James F. A. Poulet Patrik Ernfors Gary R. Lewin |
| author_facet | Julia Ojeda-Alonso Laura Calvo-Enrique Ricardo Paricio-Montesinos Rakesh Kumar Ming-Dong Zhang James F. A. Poulet Patrik Ernfors Gary R. Lewin |
| author_sort | Julia Ojeda-Alonso |
| collection | DOAJ |
| description | Abstract Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, including those signaling fast pain, were dependent on sensory Schwann cells. In polymodal nociceptors, sensory Schwann cells signal mechanical, but not cold or heat pain. Terminal Schwann cells also surround mechanoreceptor nerve-endings within the Meissner’s corpuscle and in hair follicle lanceolate endings that both signal vibrotactile touch. Within Meissner´s corpuscles, two molecularly and functionally distinct sensory Schwann cells positive for Sox10 and Sox2 differentially modulate rapidly adapting mechanoreceptor function. Using optogenetics we show that Meissner’s corpuscle Schwann cells are necessary for the perception of low threshold vibrotactile stimuli. These results show that sensory Schwann cells within diverse glio-neural mechanosensory end-organs are sensors for mechanical pain as well as necessary for touch perception. |
| first_indexed | 2024-03-07T14:51:04Z |
| format | Article |
| id | doaj.art-ee91562559af4c1c81fde4fe01d88824 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:51:04Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ee91562559af4c1c81fde4fe01d888242024-03-05T19:43:07ZengNature PortfolioNature Communications2041-17232024-02-0115111410.1038/s41467-024-44845-8Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociceptionJulia Ojeda-Alonso0Laura Calvo-Enrique1Ricardo Paricio-Montesinos2Rakesh Kumar3Ming-Dong Zhang4James F. A. Poulet5Patrik Ernfors6Gary R. Lewin7Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular MedicineDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska InstitutetNeural Circuits and Behavior, Max Delbrück Center for Molecular MedicineDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska InstitutetNeural Circuits and Behavior, Max Delbrück Center for Molecular MedicineDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska InstitutetMolecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular MedicineAbstract Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, including those signaling fast pain, were dependent on sensory Schwann cells. In polymodal nociceptors, sensory Schwann cells signal mechanical, but not cold or heat pain. Terminal Schwann cells also surround mechanoreceptor nerve-endings within the Meissner’s corpuscle and in hair follicle lanceolate endings that both signal vibrotactile touch. Within Meissner´s corpuscles, two molecularly and functionally distinct sensory Schwann cells positive for Sox10 and Sox2 differentially modulate rapidly adapting mechanoreceptor function. Using optogenetics we show that Meissner’s corpuscle Schwann cells are necessary for the perception of low threshold vibrotactile stimuli. These results show that sensory Schwann cells within diverse glio-neural mechanosensory end-organs are sensors for mechanical pain as well as necessary for touch perception.https://doi.org/10.1038/s41467-024-44845-8 |
| spellingShingle | Julia Ojeda-Alonso Laura Calvo-Enrique Ricardo Paricio-Montesinos Rakesh Kumar Ming-Dong Zhang James F. A. Poulet Patrik Ernfors Gary R. Lewin Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception Nature Communications |
| title | Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception |
| title_full | Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception |
| title_fullStr | Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception |
| title_full_unstemmed | Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception |
| title_short | Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception |
| title_sort | sensory schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception |
| url | https://doi.org/10.1038/s41467-024-44845-8 |
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