Long range inter-chromosomal interaction of Oct4 distal enhancer loci regulates ESCs pluripotency

Abstract Nuclear architecture underlies the transcriptional programs within the cell to establish cell identity. As previously demonstrated, long-range chromatin interactions of the Oct4 distal enhancer (DE) are correlated with active transcription in naïve state embryonic stem cells. Here, we ident...

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Bibliographic Details
Main Authors: Byoung-San Moon, David Huang, Fan Gao, Mingyang Cai, Guochang Lyu, Lei Zhang, Jun Chen, Wange Lu
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01363-8