CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia

CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia

Abstract Preterm infants with oxygen supplementation are at high risk for bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease. Inflammation with macrophage activation is central to the pathogenesis of BPD. CXCL10, a chemotactic and pro-inflammatory chemokine, is elevated in the lungs o...

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Bibliographic Details
Main Authors: Dharmesh V. Hirani, Florian Thielen, Siavash Mansouri, Soula Danopoulos, Christina Vohlen, Pinar Haznedar-Karakaya, Jasmine Mohr, Rebecca Wilke, Jaco Selle, Thomas Grosch, Ivana Mizik, Margarete Odenthal, Cristina M. Alvira, Celien Kuiper-Makris, Gloria S. Pryhuber, Christian Pallasch, S. van Koningsbruggen-Rietschel, Denise Al-Alam, Werner Seeger, Rajkumar Savai, Jörg Dötsch, Miguel A. Alejandre Alcazar
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Inflammation and Regeneration
Subjects:
CXCL10
Hyperoxia
Elastic fibers
Collagen
Lung matrix remodeling
Bronchopulmonary dysplasia
Online Access:https://doi.org/10.1186/s41232-023-00301-6

Internet

https://doi.org/10.1186/s41232-023-00301-6

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