Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands

Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands

G protein coupled receptors (GPCRs) bind diverse classes of ligands, and depending on the receptor, these may bind in their transmembrane or the extracellular domains, demonstrating the principal ability of GPCRs to bind ligand in either domains. Most recently, it was also observed that small molecu...

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Bibliographic Details
Main Authors: Naveena Yanamala, Judith Klein-Seetharaman
Format: Article
Language:English
Published: MDPI AG 2010-10-01
Series:Pharmaceuticals
Subjects:
rhodopsin
metabotropic glutamate receptors
allosteric network
communication
membrane proteins
Online Access:http://www.mdpi.com/1424-8247/3/10/3324/

Internet

http://www.mdpi.com/1424-8247/3/10/3324/

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