Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

Glioblastoma multiforme (GBM) are the most malignant among brain tumors. They are frequently refractory to chemotherapy and radiotherapy with mean patient survival of approximately 6 months, despite surgical intervention. The highly glycolytic nature of glioblastomas describes their propensity to me...

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Bibliographic Details
Main Authors: Chaim B Colen, Yimin Shen, Farhad Ghoddoussi, Pingyang Yu, Todd B Francis, Brandon J Koch, Michael D Monterey, Matthew P Galloway, Andrew E Sloan, Saroj P Mathupala
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800266

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http://www.sciencedirect.com/science/article/pii/S1476558611800266

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