Dimethyloxaloylglycine-stimulated human bone marrow mesenchymal stem cell-derived exosomes enhance bone regeneration through angiogenesis by targeting the AKT/mTOR pathway

Dimethyloxaloylglycine-stimulated human bone marrow mesenchymal stem cell-derived exosomes enhance bone regeneration through angiogenesis by targeting the AKT/mTOR pathway

Abstract Background Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidate agents for treating critical-sized bone defects; they promote angiogenesis and may be an alternative to cell therapy. In this study, we evaluated whether exosomes derived from bone marrow-derived M...

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Bibliographic Details
Main Authors: Bo Liang, Jia-Ming Liang, Jia-Ning Ding, Jia Xu, Jian-Guang Xu, Yi-Min Chai
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Stem Cell Research & Therapy
Subjects:
Exosome
Mesenchymal stem cell
Bone regeneration
Angiogenesis
Dimethyloxaloylglycine
Tissue engineering
Online Access:http://link.springer.com/article/10.1186/s13287-019-1410-y

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http://link.springer.com/article/10.1186/s13287-019-1410-y

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