Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma

Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma

Multiple myeloma grows by establishing multiple interactions with bone marrow cells. These include expansion of myeloid-derived suppressor cells, which drive immunoevasion via mechanisms that include arginase-1-driven depletion of L-arginine, thus indirectly promoting myeloma cell survival and tumor...

Full description

Bibliographic Details
Main Authors: Matteo Trudu, Laura Oliva, Ugo Orfanelli, Alessandra Romano, Francesco Di Raimondo, Francesca Sanvito, Maurilio Ponzoni, Simone Cenci
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
AKT
arginine
autophagy
mammalian target of rapamycin
multiple myeloma
plasma cell
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.968208/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.968208/full

Similar Items