Retro-inversion follicle-stimulating hormone peptide-modified nanoparticles for delivery of PDK2 shRNA against chemoresistant ovarian cancer by switching glycolysis to oxidative phosphorylation

Retro-inversion follicle-stimulating hormone peptide-modified nanoparticles for delivery of PDK2 shRNA against chemoresistant ovarian cancer by switching glycolysis to oxidative phosphorylation

Abstract Background Most ovarian cancers are diagnosed at advanced stages characterized by abdominal dissemination and frequently exhibit chemoresistance. Pyruvate dehydrogenase kinase 2 (PDK2) regulates the switch between glycolysis and oxidative phosphorylation and contributes to tumor progression...

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Bibliographic Details
Main Authors: Meng Zhang, Ming Du, Xingling Qi, Yumeng Wang, Guiling Li, Congjian Xu, Xiaoyan Zhang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Cancer Nanotechnology
Subjects:
Ovarian carcinoma
Pyruvate dehydrogenase kinase 2
Chemoresistance
Targeted drug delivery
Follicle-stimulating hormone
Online Access:https://doi.org/10.1186/s12645-022-00129-8

Internet

https://doi.org/10.1186/s12645-022-00129-8

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