Beyond rational—biosensor-guided isolation of 100 independently evolved bacterial strain variants and comparative analysis of their genomes

Beyond rational—biosensor-guided isolation of 100 independently evolved bacterial strain variants and comparative analysis of their genomes

Abstract Background In contrast to modern rational metabolic engineering, classical strain development strongly relies on random mutagenesis and screening for the desired production phenotype. Nowadays, with the availability of biosensor-based FACS screening strategies, these random approaches are c...

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Bibliographic Details
Main Authors: Philipp T. Baumann, Michael Dal Molin, Hannah Aring, Karin Krumbach, Moritz-Fabian Müller, Bas Vroling, Philana V. van Summeren-Wesenhagen, Stephan Noack, Jan Marienhagen
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Biology
Subjects:
Biosensor
Fluorescence-activated cell sorting
High-throughput screening
Genome sequencing
Comparative genome analysis
Single-nucleotide polymorphism
Online Access:https://doi.org/10.1186/s12915-023-01688-x

Internet

https://doi.org/10.1186/s12915-023-01688-x

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