Hypoxia Inducible Factor 1α Plays a Key Role in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Rats

Hypoxia Inducible Factor 1α Plays a Key Role in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Rats

BackgroundLimb remote ischemic preconditioning (RIPC) protects against brain injury induced by stroke, but the underlying protective mechanisms remain unknown. As hypoxia inducible factor 1α (HIF‐1α) is neuroprotective in stroke and mediates neuroinflammation, we tested the hypothesis that HIF‐1α is...

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Bibliographic Details
Main Authors: Jian Yang, Cuiying Liu, Xiangnan Du, Menglei Liu, Xunming Ji, Huishan Du, Heng Zhao
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cerebral ischemia
hypoxia inducible factor‐1α
inflammatory cytokines
remote ischemic preconditioning
reperfusion
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.007589

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.007589

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