Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis

Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis

Osteoarthritis (OA) is a prevalent chronic degenerative joint disease worldwide. Obesity has been linked to OA, and increased free fatty acid levels (e.g., palmitate) contribute to inflammatory responses and cartilage degradation. Xanthohumol (Xn), a bioactive prenylated chalcone, was shown to exhib...

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Bibliographic Details
Main Authors: Weichao Sun, Jiaji Yue, Tianhao Xu, Yinxing Cui, Dixi Huang, Houyin Shi, Jianyi Xiong, Wei Sun, Qian Yi
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Osteoarthritis
Palmitate
Xanthohumol
Mitochondria dysfunction
NLRP3 inflammasome
AMPK/NF-κB signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023084906

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http://www.sciencedirect.com/science/article/pii/S2405844023084906

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