A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations

A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations

We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition), one Fmoc-protected hydrazide arm for reaction with aldehydes...

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Bibliographic Details
Main Authors: Benjamin Fabre, Jan Pícha, Václav Vaněk, Miloš Buděšínský, Jiří Jiráček
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molecules
Subjects:
click chemistry
multifunctional scaffold
solid-phase synthesis
protein mimics
copper
hydrazone
hydrazide
Online Access:http://www.mdpi.com/1420-3049/20/10/19310

Internet

http://www.mdpi.com/1420-3049/20/10/19310

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