Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer

Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer

Abstract Background Alterations in metabolism are one of the emerging hallmarks of cancer cells and targeting dysregulated cancer metabolism provides a new approach to developing more selective therapeutics. However, insufficient blockade critical metabolic dependencies of cancer allows the developm...

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Bibliographic Details
Main Authors: Liwei Lang, Fang Wang, Zhichun Ding, Xiangdong Zhao, Reid Loveless, Jin Xie, Chloe Shay, Peng Qiu, Yonggang Ke, Nabil F. Saba, Yong Teng
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CPI-613
GLS1
CB-839
Glutaminolysis
Combined targeting
HNSCC
Online Access:https://doi.org/10.1186/s13046-021-02207-y

Internet

https://doi.org/10.1186/s13046-021-02207-y

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