Interplay between the heterotrimeric G-protein subunits G<sub>αq </sub>and G<sub>αi2 </sub>sets the threshold for chemotaxis and TCR activation

Interplay between the heterotrimeric G-protein subunits G<sub>αq </sub>and G<sub>αi2 </sub>sets the threshold for chemotaxis and TCR activation

<p>Abstract</p> <p>Background</p> <p>TCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic response towards the CXCR4 ligand CXCL12, while T cells exposed to CXCL12 are less prone to subsequent TCR-activat...

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Bibliographic Details
Main Authors: Inngjerdingen Marit, Ngai Jacob, Berge Torunn, Taskén Kjetil
Format: Article
Language:English
Published: BMC 2009-05-01
Series:BMC Immunology
Online Access:http://www.biomedcentral.com/1471-2172/10/27

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http://www.biomedcentral.com/1471-2172/10/27

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