DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity

DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity

Patients and models of cystic fibrosis (CF) exhibit consistent abnormalities of polyunsaturated fatty acid composition, including decreased linoleate (LA) and docosahexaenoate (DHA) and variably increased arachidonate (AA), related in part to increased expression and activity of fatty acid desaturas...

Full description

Bibliographic Details
Main Authors:	Sarah W. Njoroge, Michael Laposata, Waddah Katrangi, Adam C. Seegmiller
Format:	Article
Language:	English
Published:	Elsevier 2012-02-01
Series:	Journal of Lipid Research
Subjects:	fatty acid metabolism gene expression omega-3 fatty acids docosapentaenoate eicosapentaenoate
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520407837

Similar Items

A Head‐to‐Head Comparison of a Free Fatty Acid Formulation of Omega‐3 Pentaenoic Acids Versus Icosapent Ethyl in Adults With Hypertriglyceridemia: The ENHANCE‐IT Study
by: Kevin C. Maki, et al.
Published: (2022-03-01)

Athletes Can Benefit from Increased Intake of EPA and DHA—Evaluating the Evidence
by: Maja Tomczyk, et al.
Published: (2023-11-01)

Differentiating EPA from EPA/DHA in cardiovascular risk reduction
by: Peter P. Toth, et al.
Published: (2022-05-01)

Derivation of the Omega-3 Index from EPA and DHA Analysis of Dried Blood Spots from Dogs and Cats
by: William S. Harris, et al.
Published: (2022-12-01)

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4
by: Julie A. Eclov, et al.
Published: (2015-12-01)

Fish Oil Enriched in EPA, but Not in DHA, Reverses the Metabolic Syndrome and Adipocyte Dysfunction Induced by a High-Fat Diet
by: Roberta Dourado Cavalcante da Cunha de Sá, et al.
Published: (2021-02-01)

Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA
by: Simon eDyall
Published: (2015-04-01)

Importance of EPA and DHA Blood Levels in Brain Structure and Function
by: Clemens von Schacky
Published: (2021-03-01)

Changes of Erythrocyte Fatty Acids after Supplementation with Highly Concentrated Docosahexaenoic Acid (DHA) in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial
by: Roser Ayats-Vidal, et al.
Published: (2023-05-01)

Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase[S]
by: Eleanor P. Dobson, et al.
Published: (2013-05-01)

Pilot study of the effect of EPA + DHA supplementation on the fatty acid profile of erythrocytes and breast milk of lactating women from Sonsón, Colombia
by: Alejandra Valencia-Naranjo, et al.
Published: (2022-01-01)

Short-Term Intake of Yellowstripe Scad versus Salmon Did Not Induce Similar Effects on Lipid Profile and Inflammatory Markers among Healthy Overweight Adults despite Their Comparable EPA+DHA Content
by: Wei Lin Chang, et al.
Published: (2021-10-01)

Evaluation of Plasma AA/DHA+EPA Ratio in Obese Romanian Children
by: Huțanu Adina, et al.
Published: (2021-04-01)

Marine Cryptophytes Are Great Sources of EPA and DHA
by: Elina Peltomaa, et al.
Published: (2017-12-01)

Differential Effects of DHA- and EPA-Rich Oils on Sleep in Healthy Young Adults: A Randomized Controlled Trial
by: Michael J. Patan, et al.
Published: (2021-01-01)

The Effect of Eicosapentaenoic Acid Supplementation on Depression Remission: a Double-Blind Randomized Clinical Trial
by: Karamati, et al.
Published: (2011-12-01)

The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation
by: Martin F. Reiner, et al.
Published: (2021-02-01)

EPA and DHA containing phospholipids have contrasting effects on membrane structure
by: Samuel C.R. Sherratt, et al.
Published: (2021-01-01)

EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet[S]
by: Alexandre Pinel, et al.
Published: (2016-08-01)

A fish a day, keeps the cardiologist away! - A review of the effect of omega-3 fatty acids in the cardiovascular system
by: Soumia Peter, et al.
Published: (2013-01-01)

Oral Bioavailability of Omega-3 Fatty Acids and Carotenoids from the Microalgae <i>Phaeodactylum tricornutum</i> in Healthy Young Adults
by: Lena Stiefvatter, et al.
Published: (2021-12-01)

SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect FA translocation
by: Anthony G. Jay, et al.
Published: (2020-05-01)

Osmotrophic glucose and leucine assimilation and its impact on EPA and DHA content in algae
by: Elina T. Peltomaa, et al.
Published: (2020-01-01)

Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years
by: Ruohan Wang, et al.
Published: (2022-08-01)

Complete assessment of whole-body n-3 and n-6 PUFA synthesis-secretion kinetics and DHA turnover in a rodent model
by: Adam H. Metherel, et al.
Published: (2018-02-01)

Icosapent Ethyl Effects on Fatty Acid Profiles in Statin-Treated Patients With High Triglycerides: The Randomized, Placebo-controlled ANCHOR Study
by: Christie M. Ballantyne, et al.
Published: (2019-02-01)

Astaxanthin and eicosapentaenoic acid production by S4, a new mutant strain of Nannochloropsis gaditana
by: Michela Cecchin, et al.
Published: (2022-06-01)

Potentially Beneficial Effects on Healthy Aging by Supplementation of the EPA-Rich Microalgae <i>Phaeodactylum tricornutum</i> or Its Supernatant—A Randomized Controlled Pilot Trial in Elderly Individuals
by: Lena Stiefvatter, et al.
Published: (2022-11-01)

Nutritional Importance of Selected Fresh Fishes, Shrimps and Mollusks to Meet Compliance with Nutritional Guidelines of n-3 LC-PUFA Intake in Spain
by: Maria Dolores Mesa, et al.
Published: (2021-01-01)

Omega-3 biotechnology: A green and sustainable process for omega-3 fatty acids production
by: Xiao-Jun eJi, et al.
Published: (2015-10-01)

Omega-3 fatty acids and the treatment of depression: a review of scientific evidence
by: Ab Latif Wani, et al.
Published: (2015-09-01)

<b>Centesimal composition, fatty acids profile and the nutritional quality index of four seafood species from the southern region of Brazil
by: Isabella Peres Gualda, et al.
Published: (2018-07-01)

Microalgal biofactories: a promising approach towards sustainable omega-3 fatty acid production
by: Adarme-Vega T, et al.
Published: (2012-07-01)

Method Development and Validation for Omega-3 Fatty Acids (DHA and EPA) in Fish Using Gas Chromatography with Flame Ionization Detection (GC-FID)
by: Suryati Muhammad Alinafiah, et al.
Published: (2021-10-01)

Effect of prenatal EPA and DHA on maternal and cord blood insulin sensitivity: a secondary analysis of the mothers, omega 3, and mental health study
by: Joey A. England, et al.
Published: (2019-11-01)

Transcriptome sequencing of a keystone aquatic herbivore yields insights on the temperature-dependent metabolism of essential lipids
by: Heidrun S. Windisch, et al.
Published: (2019-11-01)

Comparative Life Cycle Assessment of EPA and DHA Production from Microalgae and Farmed Fish
by: Sarat Chandra Togarcheti, et al.
Published: (2021-09-01)

A Scoping Review of Interactions between Omega-3 Long-Chain Polyunsaturated Fatty Acids and Genetic Variation in Relation to Cancer Risk
by: Karin Yurko-Mauro, et al.
Published: (2020-06-01)

Omega-3 Polyunsaturated Fatty Acids—Vascular and Cardiac Effects on the Cellular and Molecular Level (Narrative Review)
by: Ines Drenjančević, et al.
Published: (2022-02-01)

Omega-3 Polyunsaturated Fatty Acids and Their Anti-Oxidant, Anti-Inflammatory and Neuroprotective Effects in Diabetic Retinopathy: A Narrative Review
by: Sarah Fathima, et al.
Published: (2023-07-01)