Unusual Placement of an EBV Epitope into the Groove of the Ankylosing Spondylitis-Associated HLA-B27 Allele Allows CD8+ T Cell Activation

Unusual Placement of an EBV Epitope into the Groove of the Ankylosing Spondylitis-Associated HLA-B27 Allele Allows CD8+ T Cell Activation

The human leukocyte antigen HLA-B27 is a strong risk factor for Ankylosing Spondylitis (AS), an immune-mediated disorder affecting axial skeleton and sacroiliac joints. Additionally, evidence exists sustaining a strong protective role for HLA-B27 in viral infections. These two aspects could stem fro...

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Bibliographic Details
Main Authors: Valentina Tedeschi, Josephine Alba, Fabiana Paladini, Marino Paroli, Alberto Cauli, Alessandro Mathieu, Rosa Sorrentino, Marco D’Abramo, Maria Teresa Fiorillo
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
HLA-B27
viral peptides
computational analysis
ankylosing spondylitis
Online Access:https://www.mdpi.com/2073-4409/8/6/572

Internet

https://www.mdpi.com/2073-4409/8/6/572

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