Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy

Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy

Myotonic dystrophy (DM) is a progressive, multisystem disorder affecting skeletal muscle, heart, and central nervous system. In both DM1 and DM2, microsatellite expansions of CUG and CCUG RNA repeats, respectively, accumulate and disrupt functions of alternative splicing factors, including musclebli...

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Bibliographic Details
Main Authors: Gang Chen, Russell E. Carter, John D. Cleary, Tammy S. Reid, Laura P. Ranum, Maurice S. Swanson, Timothy J. Ebner
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Neurobiology of Disease
Subjects:
Corpus callosum
flavoprotein
MBNL
Microsatellite repeats
Myotonic dystrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300032

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http://www.sciencedirect.com/science/article/pii/S0969996118300032

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