Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress

Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress

Diabetic cardiomyopathy (DCM) is a kind of heart disease that affects diabetic patients and is one of the primary causes of death. We previously demonstrated that deletion of the general control nonderepressible 2 (GCN2) kinase ameliorates cardiac dysfunction in diabetic mice. The aim of this study...

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Bibliographic Details
Main Authors: Juntao Yuan, Fang Li, Bingqing Cui, Junling Gao, Zhuoran Yu, Zhongbing Lu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
GCN2iB
diabetic cardiomyopathy
oxidative stress
lipid accumulation
Online Access:https://www.mdpi.com/2076-3921/11/7/1379

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https://www.mdpi.com/2076-3921/11/7/1379

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