A common genetic variation in GZMB may associate with cancer risk in patients with Lynch syndrome

A common genetic variation in GZMB may associate with cancer risk in patients with Lynch syndrome

Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is a common genetic predisposition to cancer due to germline mutations in genes affecting DNA mismatch repair. Due to mismatch repair deficiency, developing tumors are characterized by microsatellite instab...

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Bibliographic Details
Main Authors: Vince Kornél Grolmusz, Petra Nagy, István Likó, Henriett Butz, Tímea Pócza, Anikó Bozsik, János Papp, Edit Oláh, Attila Patócs
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Oncology
Subjects:
granzyme B
Lynch syndrome
immunotherapy
microsatellite instability
colorectal cancer
mismatch repair deficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1005066/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1005066/full

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