Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vaccination: Impact of prior exposure and sex

Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vaccination: Impact of prior exposure and sex

Background: Limited knowledge exists regarding antibody affinity maturation following mRNA vaccination in naïve vs. COVID-19 recovered individuals and potential sex differences. Methods: We elucidated post-vaccination antibody profiles of 69 naïve and 17 COVID-19 convalescent adults using pseudoviru...

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Bibliographic Details
Main Authors: Juanjie Tang, Gabrielle Grubbs, Youri Lee, Chang Huang, Supriya Ravichandran, David Forgacs, Hana Golding, Ted M Ross, Surender Khurana
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
COVID-19
Vaccine
Virus neutralization
Affinity maturation
Sex differences
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421005429

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421005429

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