Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella

Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella

Abstract Machado-Joseph disease (MJD) is a neurodegenerative disorder characterized by widespread neuronal death affecting the cerebellum. Cell therapy can trigger neuronal replacement and neuroprotection through bystander effects providing a therapeutic option for neurodegenerative diseases. Here,...

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Bibliographic Details
Main Authors: Liliana S. Mendonça, Daniel Henriques, Vanessa Fernandes, Ricardo Moreira, João Brás, Sónia Duarte, Jens C. Schwamborn, Luís Pereira de Almeida
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-53542-x

Internet

https://doi.org/10.1038/s41598-024-53542-x

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