Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase

Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase

N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in Drosophila, for which the erasure of this epigenetic mark has been ascribed to the ten-eleven translocation (TET) enzyme. Here, we re-evaluated 6mA presence and TET impact on the Drosophila genome. Using a...

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Bibliographic Details
Main Authors: Manon Boulet, Guerric Gilbert, Yoan Renaud, Martina Schmidt-Dengler, Emilie Plantié, Romane Bertrand, Xinsheng Nan, Tomasz Jurkowski, Mark Helm, Laurence Vandel, Lucas Waltzer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
DNA methylation
epigenetics
N6-methyladenine (6mA)
ten-eleven translocation (TET)
liquid chromatography coupled with mass tandem mass spectrometry (LCMS/ MS)
single-molecule real-time sequencing (SMRT-seq)
Online Access:https://elifesciences.org/articles/91655

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https://elifesciences.org/articles/91655

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