Structure of protein O-mannose kinase reveals a unique active site architecture

Structure of protein O-mannose kinase reveals a unique active site architecture

The ‘pseudokinase’ SgK196 is a protein O-mannose kinase (POMK) that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan on α-dystroglycan. However, the catalytic mechanism underlying this activity remains elusive. Here we present the crystal structure of Dan...

Full description

Bibliographic Details
Main Authors: Qinyu Zhu, David Venzke, Ameya S Walimbe, Mary E Anderson, Qiuyu Fu, Lisa N Kinch, Wei Wang, Xing Chen, Nick V Grishin, Niu Huang, Liping Yu, Jack E Dixon, Kevin P Campbell, Junyu Xiao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
muscular dystrophy
dystroglycan biosynthesis
secretory pathway kinase
Online Access:https://elifesciences.org/articles/22238

Internet

https://elifesciences.org/articles/22238

Similar Items