Cognitive Impairment in Nonagenarians: Potential Metabolic Mechanisms Revealed by the Synergy of In Silico Gene Expression Modeling and Pathway Enrichment Analysis

Cognitive Impairment in Nonagenarians: Potential Metabolic Mechanisms Revealed by the Synergy of In Silico Gene Expression Modeling and Pathway Enrichment Analysis

Previous studies examining the molecular and genetic basis of cognitive impairment, particularly in cohorts of long-living adults, have mainly focused on associations at the genome or transcriptome level. Dozens of significant dementia-associated genes have been identified, including APOE, APOC1, an...

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Bibliographic Details
Main Authors: Aleksandra Mamchur, Elena Zelenova, Irina Dzhumaniiazova, Veronika Erema, Daria Kashtanova, Mikhail Ivanov, Maria Bruttan, Mariia Gusakova, Mikhail Terekhov, Vladimir Yudin, Antonina Rumyantseva, Lorena Matkava, Irina Strazhesko, Ruslan Isaev, Anna Kruglikova, Lilit Maytesyan, Irina Tarasova, Olga Beloshevskaya, Elen Mkhitaryan, Sergey Kraevoy, Olga Tkacheva, Sergey Yudin
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
cognitive impairment
dementia
MMSE
long-living adults
TWAS
longevity
Online Access:https://www.mdpi.com/1422-0067/25/6/3344

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https://www.mdpi.com/1422-0067/25/6/3344

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