Genetic polymorphism of organic cation transporter 2 (OCT2) and its effects on the pharmacokinetics and pharmacodynamics of Metformin: a narrative review

Genetic polymorphism of organic cation transporter 2 (OCT2) and its effects on the pharmacokinetics and pharmacodynamics of Metformin: a narrative review

Abstract Background Organic cation transporter 2 (OCT2) is a renal carrier transporter protein found in the basolateral membrane of proximal epithelial cells, which facilitates active secretion of Metformin. The genetic polymorphism of OCT2 influences the pharmacodynamic and pharmacokinetic effect o...

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Bibliographic Details
Main Authors: Swathi Swaroopa Borra, Niva Rose Jane, Dhivyaprasath Palaniappan, Rupakrishnan Subramanian, Mithila Amar Patankar, Sadagoban Gopal Krishnamoorthy, Arun Kanniyappan Parthasarathy
Format: Article
Language:English
Published: SpringerOpen 2023-01-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Genetic polymorphism
OCT2
SLC22A2
Substrate drugs
Metformin
Type 2 diabetes mellitus (T2DM)
Online Access:https://doi.org/10.1186/s43042-023-00388-z

Internet

https://doi.org/10.1186/s43042-023-00388-z

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