Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

Research and therapeutic applications using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) require robust differentiation strategies. Efforts to improve hPSC-CM differentiation have largely overlooked the role of extracellular matrix (ECM). The present study investigates the ability o...

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Bibliographic Details
Main Authors: Jianhua Zhang, Zachery R Gregorich, Ran Tao, Gina C Kim, Pratik A Lalit, Juliana L Carvalho, Yogananda Markandeya, Deane F Mosher, Sean P Palecek, Timothy J Kamp
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
extracellular matrix
fibronectin
mesoderm
cardiac differentiation
pluripotent stem cells
integrin linked kinase
Online Access:https://elifesciences.org/articles/69028

Internet

https://elifesciences.org/articles/69028

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