Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier

Abstract Saltatory conduction is the propagation of action potentials along myelinated nerves, which enables fast propagation through the node of Ranvier. Recently, we demonstrated that K2P channels, TWIK-related K+ channel-1 (TREK-1), and TWIK-related arachidonic acid-activated K + channel (TRAAK),...

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Bibliographic Details
Main Authors: Hirosato Kanda, Koichi Noguchi, Yi Dai
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Brain
Subjects:
Online Access:https://doi.org/10.1186/s13041-023-01000-6